If you are planning on outlying casinos, like those in Summerlin, No. Las Vegas, Boulder Strip, Henderson, etc, etc. it's definitely a multiday job, even in & out.

However, if it's helpful, I have an Excel file that I've termed by "LV Trip Planner" which lists the casinos in address order, up & down the strip, downtown, etc. I use it for chip runs for the casinos I do visit each trip, to organize my driving around town. If you want a copy of the Exel file, LMK and I will email it to you.