Ow! Wish I could help you out a little more Mike but I'm the guy who arrives in Las Vegas and says, "I'll meet you back at the car in 3 days!" Seems like everyone is giving you good advice, I've only stayed at a couple of places, Fitzgerald's has nicer rooms than the ones we had at the Show at the Riviera but I couldn't recomend it in this case and the rooms at Circus Circus are nice but they charge too much. I like this site for user reviews: http://www.epinions.com/search/?submitted_form=searchbar&search_string=Reno&tax_name=&dyn_nav=0&dyn_nav_id=&search_vertical=2522535&searchbar_submit=Search

Have you thought about Tahoe? If your wife is a sit on the deck and read a book type, this might be something to consider. Crystal Bay or South Shore wouldn't be too bad for casino hopping but I would think there'd be more poker action in Reno if that's your choice. Good luck to you and the missus!