The casinos in Vegas make tons of money without cheating yet for some reason the State feels the need to regulate them. Even when cheating was common and well known, people still played.

The problem with the online sites is, they can alter the deal so subtly, that they could never be caught unless someone actually read the lines of code in the program where the instructions to cheat are written. You will fill your flush, or be dealt AA with the correct frequency, just not in situations where you get the most benefit. We could both fill our flush 20% of the time, but If I do it when an opponent has a straight, and you do it when everyone has rags the result is different. Statistically we could never prove a thing, but the results would be very different.

At low limits, its still good practice, but with $millions at stake, and no oversight, and no way to ever catch them or prove anything, you have to be very naive to believe that everyone involved in internet poker just happens to be honest.